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Analyzing and Building Nucleic Acid Structures with 3DNA
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Analyzing and Building Nucleic Acid Structures with 3DNA

Published on: April 26, 2013

Global mapping of nucleic acid conformational space: dinucleoside monophosphate conformations and transition pathways

Gregory E Sims1, Sung-Hou Kim

  • 1Department of Chemistry, University of California at Berkeley and Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.

Nucleic Acids Research
|September 23, 2003
PubMed

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Different Types of RNA Have the Same Basic Structure
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Newman Projections

Different notations are used to represent the three-dimensional structure of molecules on two-dimensional surfaces. One of the most commonly used representations is the dash-wedge formula. The dashed wedges, solid wedges, and the plane lines indicate the groups situated behind the plane, coming out of the plane, and in the plane, respectively.
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¹H NMR of Conformationally Flexible Molecules: Temporal Resolution

At room temperature, the chair conformer of cyclohexane undergoes rapid ring flipping between two equivalent chair conformers at a rate of approximately 105 times per second. These two chair conformers are in equilibrium. The rapid ring flipping results in the interconversion of the axial proton to an equatorial proton and an equatorial to the axial proton. Such interconversions are too rapid and cannot be detected on the NMR timescale. Hence, the NMR spectrometer cannot distinguish between the...
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¹H NMR of Conformationally Flexible Molecules: Variable-Temperature NMR

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Nucleic Acid Structure

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