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Related Experiment Videos

Assessing exposure misclassification by expert assessment in multicenter occupational studies.

Andrea 't Mannetje1, Joelle Fevotte, Tony Fletcher

  • 1International Agency for Research on Cancer, Lyon, France. mannetje@iarc.fr

Epidemiology (Cambridge, Mass.)
|September 23, 2003
PubMed
Summary

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Expert assessment of occupational exposure to lung carcinogens showed fair to good reliability among teams. However, agreement varied significantly across different agents, impacting risk estimates.

Area of Science:

  • Occupational Health
  • Epidemiology
  • Environmental Health

Background:

  • Assessed occupational agent exposure in a multicenter lung cancer case-control study.
  • Investigated interteam agreement among expert raters to quantify exposure misclassification.

Purpose of the Study:

  • Estimate levels of exposure misclassification by expert teams.
  • Determine expected attenuation of risk estimates due to misclassification.

Main Methods:

  • Eight expert teams and a reference rater evaluated exposure to 70 agents for 19 jobs.
  • Calculated interrater agreement using Cohen's kappa, sensitivity, and specificity.

Main Results:

  • Teams showed fair to good agreement with the reference (kappa 0.53-0.64).

Related Experiment Videos

  • Agreement on exposure presence was excellent for 9 agents, fair-good for 16, and poor for 29.
  • Specificity was high (avg. 0.94), but sensitivity varied widely across agents.

    • Conclusions:

    • Expert reliability showed minor differences among teams but significant variation among agents.
    • Presents expected misclassification ranges and odds ratio attenuation for expert occupational exposure assessments.