Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Malignant hyperthermia.

Norman J Halliday1

  • 1Department of Anesthesiology, University of Miami, Miami, FL 33136, USA. nhalliday@med.miami.edu

The Journal of Craniofacial Surgery
|September 23, 2003
PubMed
Summary
This summary is machine-generated.

Malignant Hyperthermia (MH) is a rare but life-threatening anesthesia complication. Prompt treatment with dantrolene is crucial for survival and preventing recurrence.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same journal

The Impact of Child Life Intervention on Psychological Status and Quality of Life in Children With Cleft Lip and Palate.

The Journal of craniofacial surgery·2026
Same journal

Further Considerations for Objective Facial Paralysis Assessment.

The Journal of craniofacial surgery·2026
Same journal

Microsurgical Anatomy and Surgical Relevance of the Internal Frontal Arteries: A Cadaveric Anatomic Study.

The Journal of craniofacial surgery·2026
Same journal

Pharyngeal Airway Changes Following Bimaxillary Orthognathic Surgery in Asian Patients.

The Journal of craniofacial surgery·2026
Same journal

Endoscopic Transcaruncular Approach for Early Anterior Ethmoidal Artery Cauterization in Large Olfactory Groove Meningioma Surgery: Intraoperative Video.

The Journal of craniofacial surgery·2026
Same journal

Clinical Manifestation of Congenital Unilateral Lower Lip Palsy: A Study of 111 Patients.

The Journal of craniofacial surgery·2026
See all related articles

Area of Science:

  • Anesthesiology
  • Medical Genetics
  • Pharmacology

Background:

  • Malignant Hyperthermia (MH) is a severe hypermetabolic crisis triggered by specific anesthetic agents.
  • Historically, MH was often fatal, but advancements have improved understanding and treatment.
  • It is the only known clinical condition directly caused by anesthetic agents.

Purpose of the Study:

  • To review the genetics, pathophysiology, and treatment of Malignant Hyperthermia.
  • To highlight the critical role of dantrolene in managing MH episodes.
  • To discuss diagnostic methods and patient management strategies.

Main Methods:

  • Review of historical case reports and scientific literature on Malignant Hyperthermia.
  • Analysis of the pathophysiology involving intracellular calcium regulation in skeletal muscle.

Related Experiment Videos

  • Examination of clinical presentation, triggering agents, and management protocols.

    • Main Results:

    • MH incidence ranges from 1:62,000 to 1:84,000 with specific anesthetics.
    • Masseter muscle rigidity can indicate MH risk.
    • Intravenous dantrolene is the definitive treatment, significantly reducing mortality.

    Conclusions:

    • MH is a treatable condition with timely intervention and dantrolene administration.
    • Post-MH care includes intensive monitoring, continued dantrolene, patient counseling, and MHAUS registration.
    • Caffeine/halothane muscle biopsy testing remains the definitive diagnostic method for MH susceptibility.