Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Apoptotic cell death in atherosclerosis.

Trevor D Littlewood1, Martin R Bennett

  • 1University of Cambridge, Department of Medicine, Addenbrooke's Centre for Clinical Investigation, Addenbrooke's Hospital, Cambridge, UK. tdl2@mole.bio.cam.ac.uk

Current Opinion in Lipidology
|September 23, 2003
PubMed
Summary

Apoptosis, or programmed cell death, plays a key role in atherosclerosis. Understanding the triggers and cell types involved in vascular apoptosis is crucial for developing new treatments for this disease.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Delineation of a thrombin receptor-stimulated vascular smooth muscle cell transition generating cells in the plaque-stabilizing fibrous cap.

Cardiovascular research·2025
Same author

Network-based prioritization and validation of regulators of vascular smooth muscle cell proliferation in disease.

Nature cardiovascular research·2024
Same author

Coronavirus disease 2019-related myocardial injury is associated with immune dysregulation in symptomatic patients with cardiac magnetic resonance imaging abnormalities.

Cardiovascular research·2024
Same author

Evaluation of microcirculatory protection in percutaneous revascularisation: A stent implantation technique and device comparison.

Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions·2024
Same author

Network-based prioritization and validation of regulators of vascular smooth muscle cell proliferation in disease.

Nature cardiovascular research·2024
Same author

Effect of variability of mechanical properties on the predictive capabilities of vulnerable coronary plaques.

Computer methods and programs in biomedicine·2024

Area of Science:

  • Cardiovascular Biology
  • Cellular Biology
  • Pathology

Background:

  • Apoptosis is essential for maintaining tissue homeostasis, including in the vasculature.
  • Inflammatory processes within atherosclerotic lesions trigger apoptosis via cell-cell contact, cytokines, and oxidized lipids.

Purpose of the Study:

  • To review the significance of apoptosis in atherosclerosis.
  • To identify key regulators and cell types involved in vascular cell death within atherosclerotic plaques.
  • To elucidate the mechanisms driving apoptosis in the context of cardiovascular disease.

Main Methods:

  • Literature review of recent studies on apoptosis in atherosclerosis.
  • Analysis of cellular, cytokine, and molecular regulators of apoptosis.
  • Investigation of cell types undergoing apoptosis and their contribution to plaque instability.

Related Experiment Videos

Main Results:

  • Recent studies confirm the critical role of cell death in atherosclerosis.
  • Key cellular, cytokine, and molecular regulators of apoptosis in atherosclerotic lesions have been identified and their mechanisms elucidated.
  • The specific cells undergoing apoptosis that contribute to plaque instability are being identified.

Conclusions:

  • Understanding the cell types undergoing apoptosis, extracellular factors, and intracellular mechanisms is vital.
  • This knowledge aids in designing in-vivo experiments using animal models.
  • Ultimately, this research aims to translate findings into clinical practice for atherosclerosis treatment.