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Alpha blocker therapy for children with dysfunctional voiding and urinary retention.
Mark P Cain1, Simon D Wu, Paul F Austin
1Department of Urology, Indiana University School of Medicine, Indianapolis, USA. mpcain@iupui.edu
The Journal of Urology
|September 23, 2003
Summary
Selective alpha blocker therapy significantly improved bladder emptying in children with voiding dysfunction and poor bladder emptying. This treatment reduced post-void residual urine by 88%, offering a safe and effective option for pediatric urinary retention.
Area of Science:
- Pediatric Urology
- Pharmacology
- Urodynamics
Background:
- Voiding dysfunction in children often involves poor bladder emptying.
- Alpha blockers have shown promise in managing complex cases.
- The efficacy in uncomplicated cases requires further evaluation.
Purpose of the Study:
- To assess the safety and efficacy of selective alpha blocker therapy.
- To evaluate its use in children with uncomplicated voiding dysfunction and poor bladder emptying.
- To determine its impact on post-void residual urine.
Main Methods:
- A cohort of 55 children with voiding dysfunction and increased post-void residual (PVR) were treated with doxazosin.
- Patients received dosages ranging from 0.5 mg to 2.0 mg daily.
- PVR was reassessed via bladder ultrasound after 6 weeks of treatment.
Main Results:
- Doxazosin treatment resulted in a significant decrease in average PVR from 65 ml to 8 ml.
- This represents an 88% reduction in residual urine.
- Only two patients discontinued medication due to minor side effects.
Conclusions:
- Selective alpha blocker therapy is effective in improving bladder emptying in children with specific voiding issues.
- It can serve as an alternative or adjunct to biofeedback for urinary retention.
- Further research, including randomized trials, is recommended to confirm these findings.