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Polyethylene glycol 3350 for constipation in children with dysfunctional elimination
Brad A Erickson1, J Christopher Austin, Christopher S Cooper
1Division of Pediatric Urology, Children's Hospital of Iowa, Iowa City, USA.
The Journal of Urology
|September 23, 2003
Summary
Polyethylene glycol 3350 effectively treats constipation in children with daytime wetting, improving bowel regularity and reducing urinary symptoms. Persistent constipation, however, is linked to poorer outcomes in treating dysfunctional elimination.
Area of Science:
- Pediatric Gastroenterology
- Pediatric Urology
Background:
- Daytime wetting in children is frequently associated with constipation.
- Effective constipation management is crucial for achieving dryness in children.
Purpose of the Study:
- To evaluate the efficacy of polyethylene glycol 3350 in treating constipation in children with dysfunctional elimination.
- To assess the impact of polyethylene glycol 3350 on daytime wetting and urodynamic parameters.
Main Methods:
- A review of polyethylene glycol 3350 use in 46 children (35 girls, 11 boys) with dysfunctional elimination.
- Noninvasive urodynamic studies and post-void residual measurements were conducted before and during treatment.
Main Results:
- Polyethylene glycol 3350 significantly increased bowel movement frequency (p = 0.0001).
- 18 children became dry, 26 showed decreased wetting, and 2 had no improvement.
- Voided volume increased and post-void residual decreased significantly (p <0.0001).
- Persistent constipation correlated with poorer resolution of voiding symptoms and higher post-void residuals.
Conclusions:
- Polyethylene glycol 3350 is effective and well-tolerated for treating constipation in children with dysfunctional elimination.
- Resolving constipation is key to improving voiding symptoms and reducing post-void residuals.
- Persistent constipation negatively impacts treatment outcomes for daytime wetting.