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Related Experiment Video

Updated: Feb 19, 2026

Standard Membrane Feeding Assay for the Detection of Plasmodium falciparum Infection in Anopheles Mosquito Vectors

Standard Membrane Feeding Assay for the Detection of Plasmodium falciparum Infection in Anopheles Mosquito Vectors

Published on: May 12, 2022

Malaria.

Kathryn Maitland¹, Phillip Bejon, Charles R J C Newton

¹The Centre for Geographic Medicine Research, Coast, KEMRI, Kilifi, Kenya. kmaitland@kilifi.mimcom.net

Current Opinion in Infectious Diseases

|September 23, 2003

Summary

Severe malaria is increasing globally, with acidosis as a key prognostic factor. Novel treatments and vaccines show promise but require further large-scale trials for efficacy confirmation.

Area of Science:

Tropical Medicine
Infectious Diseases
Parasitology

Background:

Global malaria burden is rising, impacting endemic regions and increasing imported cases in non-endemic areas.
Severe malaria mortality remains high due to rapid progression, with acidosis being a critical prognostic indicator.
Existing treatments for severe malaria show some efficacy, but larger trials are needed to confirm mortality benefits.

Purpose of the Study:

To review recent advancements in severe malaria pathogenesis and treatment strategies.
To highlight the increasing global prevalence of malaria.
To summarize the current status of malaria vaccine clinical trials.

Main Methods:

Literature review of recent developments in malaria research.

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Analysis of clinical trial data for malaria vaccines and treatments.

Synthesis of information on malaria epidemiology and pathogenesis.

Main Results:

Severe malaria pathogenesis is better understood, leading to novel therapeutic strategies.
Acidosis is identified as the most significant prognostic factor in severe malaria cases.
Several malaria vaccines are in early-phase trials (Phase I/II), but their immediate impact on global control is uncertain.

Conclusions:

Novel therapeutic strategies for severe malaria require validation in large-scale Phase III clinical trials.
Significant progress in malaria vaccine development is noted, with ongoing trials.
Continued research is crucial for combating the rising global malaria burden and improving patient outcomes.