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Related Experiment Videos

Echinococcus multilocularis.

Philip Craig1

  • 1Bioscience Research Institute and School of Environment and Life Sciences, University of Salford, Salford, Greater Manchester, M5 4WT, UK. p.s.craig@salford.ac.uk

Current Opinion in Infectious Diseases
|September 23, 2003
PubMed
Summary
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Human alveolar echinococcosis, a severe liver disease caused by Echinococcus multilocularis, is a growing concern in Europe. New diagnostic tools and potential treatments are being developed to combat this parasitic zoonosis.

Area of Science:

  • Veterinary Parasitology
  • Zoonotic Diseases
  • Public Health

Background:

  • Echinococcus multilocularis is a fox tapeworm causing human alveolar echinococcosis (AE), a serious liver disease.
  • AE is a rare but potentially fatal zoonotic infection, endemic in the Northern Hemisphere.
  • Radical liver resection is the only current cure, highlighting the need for improved interventions.

Purpose of the Study:

  • To review recent advancements in the pathology, diagnosis, treatment, and transmission of Echinococcus multilocularis.
  • To address the increasing prevalence and distribution of E. multilocularis in European red foxes.
  • To explore emerging diagnostic and therapeutic strategies for human alveolar echinococcosis.

Main Methods:

  • Review of recent literature on E. multilocularis pathology, diagnosis, treatment, and transmission.

Related Experiment Videos

  • Analysis of retrospective data on human AE cases in Europe.
  • Evaluation of new diagnostic tools (immunodiagnosis, coproantigen/DNA detection) and therapeutic approaches (in-vitro culture, vaccine candidates).

    • Main Results:

    • E. multilocularis prevalence in foxes is increasing in Europe, with significant human AE cases reported in France, Germany, Switzerland, China, and Japan.
    • Improved immunodiagnosis and in-vitro culture techniques enhance diagnostic accuracy and drug screening.
    • Novel copro-detection tools and landscape ecology models aid epidemiological and transmission studies.

    Conclusions:

    • Human AE may emerge as a significant zoonotic threat in Europe and Eurasia.
    • Advancements in diagnostics and treatments are under investigation.
    • Controlling E. multilocularis in wild hosts is challenging, but local transmission may be reduced through anthelminthic baits and domestic dog treatment.