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In vivo phospholipid modification induces changes in microsomal delta 5-desaturase activity
1Instituto de Investigaciones Bioquímicas de La Plata (INIBIOLP), CONICET-UNLP, Facultad de Ciencias Médicas, Argentina.
Biochimica Et Biophysica Acta
|December 2, 1992
Abstract:
The phospholipid composition of rat-liver microsomes was modified by feeding weaning rats a choline-free diet. After 21 days, the phosphatidylcholine content decreased with a concomitant increment of phosphatidylserine and cholesterol. The bulk fluidity of the membrane decreased. Under these conditions, the delta 5-desaturase activity was diminished as well as the arachidonic-acid content of the membrane lipids.