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Multicomponent coupling reactions for organic synthesis: chemoselective reactions with amide-aldehyde mixtures
Axel Jacobi von Wangelin1, Helfried Neumann, Dirk Gördes
1Leibniz-Institut für Organische Katalyse (IfOK) , Universität Rostock e.V., Buchbinderstrasse 5-6, 18055 Rostock, Germany.
Chemistry (Weinheim an Der Bergstrasse, Germany)
|September 23, 2003
Abstract:
The acid-catalyzed condensation chemistry of simple amides and aldehydes provides a highly prolific source of diverse reactants for irreversible follow-up reactions. Amide-aldehyde mixtures have been successfully employed in multicomponent syntheses of N-acyl alpha-amino acids (via palladium-catalyzed amidocarbonylation) and various cyclohexene, cyclohexadiene, and benzene derivatives (via the amide-aldehyde-dienophile (AAD) reaction).