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Weakly oriented liquid-crystal NMR solvents as a general tool to determine relative configurations
Christie Aroulanda1, Valérie Boucard, François Guibé
1Laboratoire de Chimie Structurale Organique, ESA CNRS 8074, Université Paris-Sud, ICMMO, Bât. 410, 91405 Orsay Cedex, France.
Chemistry (Weinheim an Der Bergstrasse, Germany)
|September 23, 2003
Abstract:
A new NMR method to determine the relative configuration of asymmetric centres is presented. It proceeds through the use of a weakly ordered solvent and the measurement of orientational order parameters. The method is illustrated by using dihydropyridone derivatives for which the orientations and the relative configurations of the asymmetric carbon atoms are determined unambiguously.