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Updated: Aug 18, 2026

Long-term Potentiation of Perforant Pathway-dentate Gyrus Synapse in Freely Behaving Mice
Published on: November 29, 2013
Copper interaction on the long-term potentiation
J Leiva1, P Gaete, M Palestini
1Programa de Patología, Instituto de Ciencias Biomédicas, Facultad de Medicina, Campus Oriente, Universidad de Chile, Casilla 16038, Santiago 9, Chile.
Abstract:
The role of copper on the CA1 piramidal neurons and their sinaptic connections to the Schaffer's collateral was investigated using the field excitatory post-sinaptic potential (fEPSP). The same fEPSP was used to study copper effects on Long-term potentiation (LTP). We have found that copper 10 microM has an inhibitory action on the fEPSP. Similar effects were demonstrated with 10 microM of GABA. Moreover, copper showed a strong inhibitory action on the consolidated LTP. However, copper washout left a significant and persistent excitatory response. In our opinion, copper shows a dual sinaptic effect depending on the sinaptic experience.
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