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Language comprehension in schizophrenics and their brothers.

R Condray1, S R Steinhauer, G Goldstein

  • 1Highland Drive VA Medical Center, Pittsburgh, PA 15206.

Biological Psychiatry
|November 1, 1992
PubMed
Summary
This summary is machine-generated.

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Schizophrenia vulnerability is linked to impaired language comprehension. This deficit is more pronounced in relatives with schizophrenia-spectrum disorders, suggesting a familial connection.

Area of Science:

  • Neuroscience
  • Psychiatry
  • Cognitive Psychology

Background:

  • Familial vulnerability to schizophrenia may involve cognitive deficits.
  • Language disturbances are potential endophenotypes for schizophrenia.

Purpose of the Study:

  • To investigate language comprehension in individuals with schizophrenia and their relatives.
  • To determine if impaired language comprehension is associated with familial risk for schizophrenia.

Main Methods:

  • Assessed language comprehension using the Luria-Nebraska Relational Concepts Factor Scale.
  • Evaluated 36 schizophrenic probands, 41 nonschizophrenic brothers, and 18 normal controls.
  • Administered Wisconsin Card Sorting Test and WAIS-R for control measures.

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Main Results:

  • Schizophrenia-spectrum disordered brothers showed significantly reduced language comprehension.
  • Probands and spectrum-disordered brothers had higher rates of abnormal language performance.
  • Language comprehension deficits were specific, not linked to general intellect or nonlinguistic concept formation.

Conclusions:

  • Impaired language comprehension is associated with familial vulnerability to schizophrenia.
  • Language deficits may be more severe in relatives diagnosed with schizophrenia-spectrum disorders.
  • Language comprehension may serve as a potential endophenotype in schizophrenia spectrum disorders.