Related Experiment Video
Updated: Aug 10, 2026

Intracoronary Acetylcholine Provocation Testing for Assessment of Coronary Vasomotor Disorders
Published on: August 18, 2016
[Effect of physical training on M-cholinergic-blocking activity of blood serum in acute coronary disease]
S V Mal'chikova1, E N Sizova, V I Tsirkin
1Kirov State Medical Academy, Viatka State Humanitarian University, Russia, 610002, 111 Lenin St., Kirov.
Abstract:
On 93 longitudinal strips of 31 rats' uterus horns, M-cholinoblocking agent activity in 50-, 100-, 500-, 1000- and 10,000-fold dilution of the blood serum taken from 10 healthy older subjects and 40 patients after an acute coronary incident, was studied, 10 patients being engaged in physical training. Findings suggest presence of an endogenous M-cholinoreceptor blocking agent in the blood with lisophosphatidylcholin as the basic component. An acute coronary incident seems to reduce the efficiency of the M-cholinergic effect on the heart and vessels.
Related Concept Videos
Direct-Acting Cholinergic Agonists: Chemistry and Structure-Activity Relationship
The direct-acting...
Direct-Acting Cholinergic Agonists: Pharmacokinetics
Direct-Acting Cholinergic Agonists: Pharmacological Actions
Direct-Acting Cholinergic Agonists: Therapeutic Uses
Indirect-Acting Cholinergic Agonists: Pharmacological Actions
At the neuromuscular junction, these agents work by inhibiting the breakdown of acetylcholine, allowing it to remain bound to the receptor and bind to nearby receptors. This process leads to repetitive firing of the endplate, causing muscle...
Antianginal Drugs: Nitrates and β-Blockers
Organic nitrates, such as nitroglycerin, play a pivotal role. Once metabolized, they liberate nitric oxide, a molecular marvel. Nitric oxide triggers guanylyl cyclase and augments cGMP production. This biochemical cascade orchestrates the relaxation of vascular smooth muscles, ushering in vasodilation and enhancing coronary blood flow. Administered...

