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Updated: Aug 31, 2026
Murine Model of Allergen Induced Asthma
Published on: May 14, 2012
[Effect of pingchuan mixture on eosinophil cation protein and interleukin-5 in experimental guinea pigs with asthma]
Xiang-ming Fang1, Shi-hong Cao
1Anhui TCM College, Hefei 230038. fxm.bsh@163.com
Objective:
To observe the effect of Pingchuan Mixture (PCM) on plasma eosinophil cation protein (ECP), interleukin-5 in bronchial alveolar lavage fluid (BALF) and inflammatory cell count in experimental guinea pigs with asthma.
Methods:
The eosinophil, neutrophil, lymphocyte count were conducted by conventional method, IL-5 was detected by ELISA and ECP determined by RIA.
Results:
Levels of eosinophil, neutrophil, lymphocyte, ECP and IL-5 after treatment were significantly lower than those before treatment, the difference between groups treated respectively by PCM, aminophylline, dexamethasone and Dingchuan Zhike Tablet was insignificant.
Conclusion:
PCM could treat asthma by reducing the inflammatory cell count, ECP and IL-5.
