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Drug supplementation in pregnancy.

J T Repke1

  • 1Harvard Medical School, Brigham and Women's Hospital, Boston, Massachusetts.

Current Opinion in Obstetrics & Gynecology
|December 1, 1992
PubMed
Summary

This review explores historical and current uses of nutritional and drug supplementation during pregnancy. It highlights key supplements like iron, folic acid, and aspirin for improving pregnancy outcomes and preventing birth defects.

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Area of Science:

  • Obstetrics and Gynecology
  • Nutritional Science
  • Pharmacology

Background:

  • Historical medical texts document the influence of nutrition on pregnancy outcomes.
  • Geophagia (eating earth) was studied for potential adaptive benefits on birth outcomes.
  • Recent research focuses on nutritional and drug supplementation for pregnancy-induced hypertension and teratogenesis.

Purpose of the Study:

  • To review the role of drug and nutritional supplementation in pregnancy.
  • To discuss established needs and controversial uses of supplements.
  • To examine supplements for preventing specific pregnancy complications.

Main Methods:

  • Literature review of articles on nutrition and drug supplementation in pregnancy.
  • Examination of historical and contemporary research findings.
  • Focus on specific examples like iron, folic acid, and aspirin supplementation.

Main Results:

  • Iron supplementation is crucial for preventing iron-deficiency anemia.
  • Folic acid supplementation (preconceptional) is vital for preventing neural tube defects.
  • Low-dose aspirin supplementation shows controversy in preventing preeclampsia.

Conclusions:

  • Nutritional and drug supplementation play a significant role in modern obstetrics.
  • Evidence supports specific supplements for preventing major pregnancy complications.
  • Continued research is needed to clarify optimal supplementation strategies.

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