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Published on: November 9, 2016
Paracetamol ingestions at the Children's Emergency Department--a three year series
1Department of Emergency Medicine, KK Women's & Children's Hospital, 100 Bukit Timah Road, Singapore 229899. keech@kkh.com.sg
Insights
Paracetamol is the most common cause of childhood poisoning, particularly in toddlers. While most ingestions are accidental, older children intentionally taking higher doses showed concerning paracetamol levels but no serious harm.
Area of Science:
- Pediatrics
- Toxicology
- Emergency Medicine
Background:
- Paracetamol (acetaminophen) is a leading cause of pediatric poisoning.
- Understanding ingestion patterns is crucial for prevention and management.
Purpose of the Study:
- To review paracetamol ingestions in children presenting to an emergency department.
- To identify risk factors and outcomes associated with paracetamol overdose.
Main Methods:
- Retrospective review of 96 pediatric paracetamol ingestion cases.
- Data collected on patient demographics, ingestion type, dosage, and clinical outcomes.
Main Results:
- Paracetamol accounted for 23% of childhood poisonings.
- Most ingestions (60%) were in children aged 1-3 years, predominantly accidental.
- Intentional ingestions occurred in older children (≥12 years) with higher doses and potentially serious serum levels, but no mortality or significant morbidity was observed.
Conclusions:
- Paracetamol poisoning is a significant pediatric concern, especially accidental ingestions in young children.
- Intentional overdoses in adolescents warrant close monitoring due to higher risk of severe toxicity.
- Effective management and public health strategies are essential to reduce paracetamol-related harm in children.
Abstract:
This is a three-year retrospective review of 96 cases of paracetamol ingestions seen by KK Children's Emergency Department. Paracetamol is the commonest substance (23%) involved in childhood poisonings. More than 60% occurred in children aged one to three years old with an equal gender distribution. Eighty-six percent were accidental ingestions and the intentional ones had a significant female bias, all occurring in children aged 12 and above. These older children ingested higher doses of paracetamol (average dose of 233 mg/kg) and had potentially serious serum paracetamol levels. There was no significant morbidity and no mortality in this series.
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