Related Experiment Video
Updated: Jul 14, 2026

The Treadmill Fatigue Test: A Simple, High-throughput Assay of Fatigue-like Behavior for the Mouse
Published on: May 31, 2016
Fatigue in MS is related to sympathetic vasomotor dysfunction
P Flachenecker1, A Rufer, I Bihler
1Department of Neurology, Julius-Maximilians-Universität, Würzburg, Germany. peter.flachenecker@surfeu.de
Abstract:
The authors studied standard autonomic function tests and measures of heart rate variability in 60 patients with multiple sclerosis (MS) and correlated results with the Fatigue Severity Scale and the Modified Fatigue Impact Scale. The authors found that autonomic responses correlated with fatigue resembling a hypoadrenergic orthostatic response, possibly due to a sympathetic vasomotor lesion with intact vagal heart control. Treatments to control sympathetic dysfunction for MS-associated fatigue deserve further study.
Related Concept Videos
Sympathetic Activation
Disorders of the Autonomic Nervous System
Raynaud's disease, also known as Raynaud's phenomenon, is a...
Pathophysiology of Heart Failure
Fatigue
Multiple Sclerosis l: Introduction
Myasthenia Gravis ll: Pathophysiology

