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Mycotic osteomyelitis due to Scedosporium Apiospermum: MR imaging-pathologic correlation
Malcolm K Sydnor1, Shaifali Kaushik, Thomas E Knight
1Department of Radiology, Medical College of Virginia Hospital, Virginia Commonwealth University, P. O. Box 980615, Richmond, VA 23298-0615, USA.
Skeletal Radiology
|September 25, 2003
Summary
Mycotic osteomyelitis from Scedosporium Apiospermum is rare in immunocompromised patients. Diagnosis can be delayed, necessitating prompt treatment to prevent severe outcomes.
Area of Science:
- Mycology
- Infectious Diseases
- Orthopedic Surgery
Background:
- Mycotic osteomyelitis is a rare bone infection, typically affecting immunocompromised individuals following penetrating trauma.
- Scedosporium Apiospermum is an uncommon fungal pathogen, with limited reported cases of osteomyelitis and septic arthritis.
Observation:
- This report details a rare case of Scedosporium Apiospermum osteomyelitis in an immunocompromised patient.
- The diagnosis was confirmed via histopathology from an amputation specimen, highlighting a unique diagnostic approach.
Findings:
- The patient presented with insidious onset, and initial joint fluid cultures were negative, delaying diagnosis.
- This case represents the third reported instance of S. apiospermum osteomyelitis in an immunocompromised host and the first with this specific diagnostic method.
Implications:
- Early recognition and diagnosis of Scedosporium Apiospermum are crucial for effective treatment.
- Delayed diagnosis and treatment can lead to disseminated infection and potentially fatal outcomes.