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Bilateral preaxial polydactyly: a possible dominant inheritant

Minako Nishikawa1, Nagao Bitoh, Fumitaka Kikkawa

  • 1Department of Obstetrics and Gynecology, Nagoya University School of Medicine, Tsurumai 65, Showa-ku, Nagoya 466-0064, Japan.

Archives of Gynecology and Obstetrics
|September 25, 2003
PubMed

Insights

This study details families with preaxial polydactyly, a condition affecting hands and feet. Autosomal dominant inheritance is suggested, with satisfactory surgical outcomes beneficial for antenatal counseling.

Area of Science:

  • Genetics
  • Developmental Biology
  • Orthopedic Surgery

Background:

  • Preaxial polydactyly is a congenital limb malformation affecting the thumb or great toe.
  • Understanding its genetic basis and inheritance patterns is crucial for genetic counseling.
  • Surgical intervention is often necessary to correct functional and aesthetic impairments.

Observation:

  • Families presenting with bilateral preaxial polydactyly in both hands and feet were identified.
  • Pedigree analysis indicated a strong likelihood of autosomal dominant inheritance for this trait.
  • Multiple associated congenital abnormalities were noted in affected individuals.

Findings:

  • The inheritance pattern strongly suggests autosomal dominant transmission of preaxial polydactyly.
  • Despite the presence of multiple congenital anomalies, surgical correction yielded favorable outcomes.
  • The described cases provide valuable data for the medical community.

Implications:

  • These findings contribute to the understanding of polydactyly genetics and inheritance.
  • The successful surgical outcomes highlight the potential for effective management of this condition.
  • This research is valuable for improving antenatal diagnosis and genetic counseling for affected families.

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