Biophysical model of synaptic plasticity dynamics

Henry D I Abarbanel¹, Leif Gibb, R Huerta

¹Institute for Nonlinear Science, Center for Theoretical Biological Physics, Marine Physical Laboratory (Scripps Institution of Oceanography) and Department of Physics, University of California, San Diego, La Jolla, CA 93093-0402, USA. hdia@jacobi.ucsd.edu

|September 25, 2003

Abstract:

We discuss a biophysical model of synaptic plasticity that provides a unified view of the outcomes of synaptic modification protocols, including: (1) prescribed time courses of postsynaptic intracellular Ca(2+) release, (2) postsynaptic voltage clamping with presentation of presynaptic spike trains at various frequencies, (3) direct postsynaptic response to presynaptic spike trains at various frequencies, and (4) LTP/LTD as a response to precisely timed presynaptic and postsynaptic spikes.

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Abstract:

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