Related Experiment Video
Updated: Aug 11, 2026
09:52
An Orthotopic Glioblastoma Mouse Model Maintaining Brain Parenchymal Physical Constraints and Suitable for Intravital Two-photon Microscopy
Published on: April 21, 2014
Evolution of the brain tumour spheroid model: transcending current model limitations
A Corcoran1, L I F De Ridder, D Del Duca
1Brain Tumour Research Centre, Montreal Neurological Institute, Montreal, Canada.
Acta Neurochirurgica
|September 25, 2003
Summary
Malignant brain tumour invasion into healthy tissue limits current therapies. This review highlights improved in vitro models, like the spheroid model, to study tumour cell motility and advance anti-invasion treatments.
Area of Science:
- Neuro-oncology
- Cancer Biology
- Cellular Motility
Background:
- Malignant brain tumours exhibit high recurrence and mortality rates.
- Current treatments (surgery, radiation, chemotherapy) fail to control tumour cell invasion into healthy brain tissue.
Purpose of the Study:
- To review traditional in vitro models of brain tumour invasion.
- To discuss recent advancements in the spheroid model for studying tumour cell invasion and motility.
- To accelerate the development of novel anti-invasion therapies.
Main Methods:
- Review of existing literature on in vitro models for brain tumour invasion.
- Focus on traditional models and adaptations of the spheroid model.
- Analysis of research contributions to understanding tumour migration mechanisms.
Main Results:
- Various in vitro models exist to study brain tumour invasion and cell motility.
- The spheroid model has seen significant adaptations and improvements.
- Research has advanced the understanding of mechanisms mediating brain tumour invasion.
Conclusions:
- Improved in vitro models are crucial for studying brain tumour invasion.
- Advancements in models like the spheroid model facilitate research.
- Sharing these innovations can expedite the development of effective anti-invasion brain tumour therapies.
