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Multiple esophagogastric granular cell tumors.

Hiroshi Maekawa1, Takeo Maekawa, Kiyotaka Yabuki

  • 1Department of Surgery, Izunagaoka Hospital, Juntendo University, 1129 Nagaoka Izunagaoka-cho, Tagata-gun, Shizuoka 410-2211, Japan.

Journal of Gastroenterology
|September 25, 2003
PubMed
Summary

This case report describes multiple benign granular cell tumors in the esophagus and stomach of a 53-year-old man. Surgical resection confirmed the rare diagnosis of multiple esophagogastric granular cell tumors.

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Area of Science:

  • Gastroenterology
  • Surgical Pathology

Background:

  • Granular cell tumors (GCTs) are rare neoplasms of neural crest origin.
  • While typically solitary, multiple GCTs can occur, particularly in the digestive tract.

Observation:

  • A 53-year-old male presented with multiple GCTs in the esophagus and stomach.
  • One esophageal tumor was endoscopically resected; seven gastric tumors necessitated gastrectomy.

Findings:

  • Histological analysis revealed GCTs composed of spindle or polyhedral cells with eosinophilic granules.
  • Immunohistochemistry showed positive S-100 protein staining, with low p53 and Ki-67 proliferation indices.
  • Tumors were primarily submucosal, with some extension into the esophageal and gastric propria and muscularis layers.

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Implications:

  • The findings support the diagnosis of benign multiple esophagogastric granular cell tumors.
  • This case contributes to the limited literature on multifocal GCTs in the upper digestive tract.
  • Highlights the importance of thorough evaluation for multifocal disease in GCT presentations.