Related Experiment Video
Updated: Aug 31, 2026

Genome-Wide Analysis of DNA Methylation in Gastrointestinal Cancer
Published on: September 18, 2020
Japan's contribution to clinical research in gastroenterology and hepatology
Kenji Maeda1, Mahbubur Rahman, Tsuguya Fukui
1Department of General Medicine and Clinical Epidemiology, Kyoto University Graduate School of Medicine, 54 Kawara-cho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan.
Background:
Although Japan's contributions to several biomedical fields have already been reported, little is known about Japan's contribution to gastroenterology and hepatology.
Methods:
Original articles published in 1991 through 2000 in highly reputed journals in the field of gastroenterology and hepatology were retrieved from the MEDLINE database. The number of articles having an affiliation with a Japanese institution was counted in total, and the number for each journal was also counted. Japan's share of articles regarding clinical trials and randomized controlled trials (RCTs) in this field was also determined, along with the trend over the past decade.
Results:
Japan's share of articles in this field was 10.6%, ranking third in the world, following the United States (35.1%) and the United Kingdom (11.5%). Japan's share of articles went up significantly as a whole (P = 0.01), while the share for RCTs showed no significant change ( P = 0.57) during this period of time. CONCLUSIONS; Japan's contribution to the field of gastroenterology and hepatology is, in general, acceptable compared with that of other counties, but the contribution for RCTs not satisfactory.
Related Concept Videos
Gastroesophageal Reflux Disease II: Clinical Features and Management
Clinical Manifestations
GERD presents itself in a multitude of ways, with symptoms varying from person to person. The hallmark symptoms are...
Peptic Ulcer Disease III: Clinical Manifestations and Diagnostic Studies
Few clinical manifestations differentiate gastric ulcers from duodenal ulcers. Distinctions in the location, timing, and pain relief are crucial for healthcare providers in differentiating between gastric and duodenal ulcers during clinical assessments.
Clinical Trials
There are four phases in a clinical trial. A phase one...
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the colonic...
Clinical Trials: Overview
Chronic Pancreatitis II: Collaborative Care
Assessment: