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Updated: Aug 31, 2026

Simultaneous Video-EEG-ECG Monitoring to Identify Neurocardiac Dysfunction in Mouse Models of Epilepsy
Published on: January 29, 2018
Paroxysms of excitement: sodium channel dysfunction in heart and brain
1Department of Paediatric Cardiology, Guy's Hospital, London, UK. ceh14@mole.bio.cam.ac.uk
Abstract:
Inherited disorders of ion-channels are associated with paroxysmal dysfunction of excitable tissues and manifest as diseases of the brain, heart and skeletal muscle. These so-called channelopathies have now been described for most of the major categories of voltage-dependent ion-channels including those selectively permeable to sodium. Sodium channelopathies affecting the heart and brain are reviewed in this essay. They show striking differences and similarities including, for example, their responsiveness to changes in body temperature and sleep state. They represent a paradigm for efforts to trace disturbed behaviour of physiological systems back to its molecular origins and understanding their molecular basis may provide clues to important health issues such as cardiac side effects of drugs and response to medication used to treat epilepsy.
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