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Updated: Jul 20, 2026

Measuring Fast Calcium Fluxes in Cardiomyocytes
Published on: November 29, 2011
Regulation of [Ca2+]c oscillations by plasma membrane Ca2+ fluxes: a role for natriuretic peptides
A K Green1, O Zolle, A W M Simpson
1Department of Biological Sciences, The University of Warwick, Coventry, CV4 7AL, UK. A.K.Green@warwick.ac.uk
Abstract:
We have investigated the effects of natriuretic peptides on oscillations in [Ca(2+)](c) (cytosolic free Ca(2+) concentration) in two different cell types: freshly isolated rat hepatocytes and the ECV304 cell line. Our data, from both cell types, suggest that natriuretic peptides modulate the frequency of [Ca(2+)](c) oscillations through alterations in plasma membrane Ca(2+) fluxes. Here, we review evidence for a role for plasma membrane Ca(2+) fluxes in the control of the frequency of [Ca(2+)](c) oscillations. We describe a hypothetical mechanism through which this might be achieved. We propose a physiological role for regulated control of Ca(2+) efflux in modulating [Ca(2+)](c) oscillations.
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