Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The Ras binary switch: an ideal processor for decoding complex Ca2+ signals?

S A Walker1, P J Lockyer, P J Cullen

  • 1The Henry Wellcome Laboratories for Integrated Cell Signalling, Inositide Group, Department of Biochemistry, University of Bristol, Bristol BS8 1TD, UK.

Biochemical Society Transactions
|September 25, 2003
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Fluorescent PSMA-Targeted Radiotheranostic Compounds for Multiscale Imaging.

Bioconjugate chemistry·2025
Same author

Biomolecules as Model Indicators of <i>In Vitro</i> and <i>In Vivo</i> Cold Plasma Safety.

Frontiers in physics·2023
Same author

Do naps benefit novel word learning? Developmental differences and white matter correlates.

Cortex; a journal devoted to the study of the nervous system and behavior·2022
Same author

Inactivation efficacy of atmospheric air plasma and airborne acoustic ultrasound against bacterial biofilms.

Scientific reports·2021
Same author

Developments and Challenges in Online NIR Spectroscopy for Meat Processing.

Comprehensive reviews in food science and food safety·2020
Same author

Impact of cold plasma processing on major peanut allergens.

Scientific reports·2020
Same journal

TDP-43 proteinopathy as a biomarker and therapeutic target in amyotrophic lateral sclerosis.

Biochemical Society transactions·2026
Same journal

Advancing the monitoring of organelle contact sites in vitro and in vivo.

Biochemical Society transactions·2026
Same journal

Mechanisms influencing transient cytoplasmic protein targeting to intracellular lipid droplets.

Biochemical Society transactions·2026
Same journal

Replication associated nuclear DNA mismatch repair across kingdoms.

Biochemical Society transactions·2026
Same journal

Phosphatases of regenerating liver downregulate PTEN to promote tumorigenesis.

Biochemical Society transactions·2026
Same journal

Implications of Rho GTPase signaling in cancer immunotherapy.

Biochemical Society transactions·2026
See all related articles

Cell surface receptor activation causes calcium spikes, which may be decoded by Ras proteins. Calcium-sensitive regulators of Ras proteins suggest a role in interpreting these complex calcium signals for cellular responses.

Area of Science:

  • Cellular Biology
  • Molecular Signaling
  • Biochemistry

Background:

  • Cell surface receptor activation alters intracellular calcium concentration ([Ca(2+)](i)).
  • Calcium transients often manifest as repetitive spikes, with frequency correlating to stimulus amplitude.
  • Interpreting these complex calcium signals requires molecular decoding mechanisms.

Purpose of the Study:

  • To investigate the potential role of Ras proteins in decoding complex intracellular calcium signals.
  • To explore the link between calcium transients and Ras signaling pathways.

Main Methods:

  • Analysis of calcium-regulated guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs).
  • Investigating the sensitivity of GEFs and GAPs to intracellular calcium concentration ([Ca(2+)](i)).

Related Experiment Videos

Main Results:

  • Identified calcium-regulated GEFs and GAPs with high sensitivity to intracellular calcium.
  • Evidence suggests these regulators play a role in modulating Ras protein activity.

Conclusions:

  • Complex calcium signals, characterized by varying spike frequencies, may be interpreted by molecular decoders.
  • Ras proteins, regulated by calcium-sensitive GEFs and GAPs, are implicated in translating these calcium signals into cellular responses.