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Synthesis and anticancer effect of B-ring trifluoromethylated flavonoids
Xing Zheng1, Jian-Guo Cao, Wei-Dong Meng
1College of Chemistry and Chemical Engineering, Donghua University, 1882 West Yanan Lu, Shanghai 200051, China.
Bioorganic & Medicinal Chemistry Letters
|September 25, 2003
Abstract:
A series of B-ring trifluoromethylated flavonoids derivatives were prepared and tested in vitro against human gastric adenocarcinoma cell line (SGC-7901). Among these derivatives, 5,7-dipropoxy-2-(4'-trifluoromethylphenyl)-chromen-4-one 5c had the strongest activity against SGC-7901 cell.