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Updated: Aug 31, 2026
Nitropeptide Profiling and Identification Illustrated by Angiotensin II
Published on: June 16, 2019
Synthesis and in vitro analysis of atrial natriuretic peptide-albumin conjugates
Roger Léger1, Martin Robitaille, Omar Quraishi
1Research Department, ConjuChem Inc., 225 President-Kennedy Ave., Suite 3950, Montréal, QC, Canada H2X 3Y8. leger@conjuchem.com
Abstract:
Atrial natriuretic peptide (ANP) is a clinically useful anti-hypertensive hormone. Maleimide derivatives of ANP have been synthesized and conjugated to cysteine-34 of human serum albumin. The conjugates were analyzed to assess their stability, receptor binding affinity and ability to stimulate guanylyl-cyclase activity in rat lung fibroblasts.
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