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Crystal structures of O-acetylated 2-acylamino-2-deoxy-D-galactose derivatives
Thomas Mikeska1, Martin Nieger, Heidi Mansikkamäki
1Kekulé-Institut für Organische Chemie und Biochemie der Universität, Gerhard-Domagk-Str.1, D-53121 Bonn, Germany.
Abstract:
The X-ray structures of 1,3,4,6-tetra-O-acetyl-2-deoxy-alpha-D-galactopyranoside derivatives with four different 2-(acylamino) substituents have been determined with Mo K(alpha) radiation at 123 K. The structure of the 2-acetylamino derivative and of its acyl-homologs with a 2-(propanoylamino)-, 2-(butanoylamino)-, and 2-(2-methyl-propanoylamino)-group crystallized in the monoclinic space group C2. The pyranose unit of all compounds has the usual 4C(1) shape. The different orientations of the 6-O-acetyl-groups are discussed. Conformations of the acylamino-group are compared to those found in the crystal structure of N-acetyl-alpha-D-galactosamine.
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