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Oxidative stress in diabetic retina
M Doly1, M T Droy-Lefaix, P Braquet
1Laboratoire de Biophysique (Inserm U. 71), Facultés de Médecine et de Pharmacie, Clermont-Ferrand, France.
EXS
|January 1, 1992
Summary
Diabetic retinopathy involves retinal capillary changes and blood-retinal barrier disruption. Ginkgo biloba extract (EGb 761) showed protective effects, preserving electroretinogram (ERG) amplitude in diabetic rat models.
Area of Science:
- Ophthalmology
- Diabetology
- Pharmacology
Background:
- Diabetic retinopathy is characterized by retinal capillary basement membrane thickening and increased vascular permeability, leading to blood-retinal barrier disruption.
- Oxygenated free radicals are implicated in the pathogenesis of diabetic retinopathy.
Purpose of the Study:
- To investigate the protective effects of Ginkgo biloba extract (EGb 761) against diabetic retinopathy-induced retinal dysfunction.
- To evaluate the impact of diabetes duration on retinal function in an experimental model.
Main Methods:
- Alloxan-induced diabetic rat model was used to study diabetic retinopathy.
- Electroretinograms (ERG) were recorded from isolated retinas after one and two months of diabetes.
- The protective effects of EGb 761 (100 mg/kg/day) were assessed in diabetic rats.
Main Results:
- Diabetic rat retinas showed a 20% decrease in ERG amplitude after one month and a 60% decrease after two months compared to controls.
- EGb 761 treatment significantly preserved ERG amplitude in diabetic rats after two months (p < 0.001).
Conclusions:
- Diabetic retinopathy leads to significant retinal dysfunction, exacerbated by the duration of diabetes.
- Ginkgo biloba extract (EGb 761) demonstrates potential as a therapeutic agent for preventing or mitigating retinal impairment in diabetes by acting as a free radical scavenger.