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Related Concept Videos

Cell Migration01:09

Cell Migration

Cell migration, the process by which cells move from one location to another, is essential for the proper development and viability of organisms throughout their life. When cells are not able to migrate properly to their ordained locations, various disorders may occur. For example, disruption in cell migration causes chronic inflammatory diseases such as arthritis.
Phosphoinositides and PIPs01:42

Phosphoinositides and PIPs

Phosphoinositides are a group of phospholipids containing a glycerol backbone with two fatty acid chains and a phosphate attached to a myoinositol sugar ring. The inositol head group extends into the cytoplasm, where it is modified by adding phosphate groups to form phosphatidylinositol phosphates or PIPs.
Different phosphoinositides are synthesized and recruited on the cytosolic face of the plasma membrane. The localization of specific phosphoinositides concentrated in separate membrane...
Cell Migration01:19

Cell Migration

Cell migration is a process by which the cells move from one location to another, playing an essential role in embryological development, repair and regeneration, immune response, and metastasis. Cells migrate in response to chemical or mechanical signals generated by specific organs or tissues. The overall mechanism includes three steps - polarization, protrusion, and release. Polarization involves the formation of a distinct cell front and rear, which determines the direction of movement.
Cytoskeletal Coordination in Cell Migration01:32

Cytoskeletal Coordination in Cell Migration

A migrating cell changes its shape during the cyclic events of attachment and detachment from the substratum and repositions the cell organelles correspondingly. These complex events are orchestrated by the dynamic cytoskeletal network comprising actin filaments, intermediate filaments, and microtubules. Cytoskeletal crosstalk — the direct and indirect communication between the different components — is crucial for this coordination. Direct communication involves various linker proteins that...
Overview of Cell-Matrix Interactions01:24

Overview of Cell-Matrix Interactions

The extracellular matrix or ECM holds cells together to form a tissue and allows the cells within the tissue to communicate. ECM comprises proteins such as fibronectin, collagen, laminin, etc. The most abundant protein in this space is collagen. Collagen fibers are interwoven with carbohydrate-containing protein molecules called proteoglycans. ECM allows cell migration and provides a structural scaffold at cell adhesion that anchors the cell when the extracellular matrix proteins interact with...
Intracellular Signaling Affects Focal Adhesions01:17

Intracellular Signaling Affects Focal Adhesions

Integrins act both as extracellular input receivers and as intracellular processing activators. As their name suggests, integrins are entirely integrated into the membrane structure. Their hydrophobic membrane-spanning regions interact with the phospholipid bilayer's hydrophobic region. These membrane receptors provide extracellular attachment sites for effectors like hormones and growth factors. They activate intracellular response cascades when their effectors are bound and active.
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Related Experiment Video

Updated: May 7, 2026

Quantitative Measurement of Invadopodia-mediated Extracellular Matrix Proteolysis in Single and Multicellular Contexts
14:23

Quantitative Measurement of Invadopodia-mediated Extracellular Matrix Proteolysis in Single and Multicellular Contexts

Published on: August 27, 2012

Phosphatases in cell-matrix adhesion and migration.

Melinda Larsen1, Michel L Tremblay, Kenneth M Yamada

  • 1Craniofacial Developmental Biology and Regeneration Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Building 30/Room 421, 30 Convent Drive, MSC 4370, Bethesda, Maryland 20892-4370, USA. mlarsen@mail.nih.gov

Nature Reviews. Molecular Cell Biology
|September 25, 2003
PubMed
Summary
This summary is machine-generated.

Phosphatases, enzymes that remove phosphate groups, are crucial for cell migration and adhesion. They regulate the actin cytoskeleton, GTPase switches, and cell movement dynamics, complementing the known roles of kinases.

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Methods to Study Mrp4-containing Macromolecular Complexes in the Regulation of Fibroblast Migration
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Methods to Study Mrp4-containing Macromolecular Complexes in the Regulation of Fibroblast Migration

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Related Experiment Videos

Last Updated: May 7, 2026

Quantitative Measurement of Invadopodia-mediated Extracellular Matrix Proteolysis in Single and Multicellular Contexts
14:23

Quantitative Measurement of Invadopodia-mediated Extracellular Matrix Proteolysis in Single and Multicellular Contexts

Published on: August 27, 2012

Using Cell-substrate Impedance and Live Cell Imaging to Measure Real-time Changes in Cellular Adhesion and De-adhesion Induced by Matrix Modification
09:11

Using Cell-substrate Impedance and Live Cell Imaging to Measure Real-time Changes in Cellular Adhesion and De-adhesion Induced by Matrix Modification

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Methods to Study Mrp4-containing Macromolecular Complexes in the Regulation of Fibroblast Migration
10:43

Methods to Study Mrp4-containing Macromolecular Complexes in the Regulation of Fibroblast Migration

Published on: May 19, 2016

Area of Science:

  • Cell Biology
  • Biochemistry
  • Molecular Biology

Background:

  • Protein phosphorylation by kinases regulates proteins involved in cell-matrix adhesion and migration.
  • Kinases are known regulators of cell motility.
  • Emerging evidence highlights the critical role of phosphatases in cell migration.

Purpose of the Study:

  • To elucidate the essential roles of phosphatases in various stages of cell migration.
  • To understand how phosphatases influence the molecular mechanisms underlying cell motility.

Main Methods:

  • The study reviews existing literature on protein phosphorylation and dephosphorylation in cell migration.
  • Analysis of the regulatory functions of phosphatases on actin cytoskeleton dynamics.
  • Investigation of phosphatase involvement in small GTPase signaling pathways.

Main Results:

  • Phosphatases are essential regulators at all stages of cell migration.
  • They control actin cytoskeleton formation, maintenance, and dynamics.
  • Phosphatases modulate small GTPase molecular switches, matrix-adhesion interactions, and cell migratory directionality.

Conclusions:

  • Phosphatases play a vital, multifaceted role in cell migration, acting in concert with kinases.
  • Understanding phosphatase function is key to comprehending cell motility regulation.
  • Targeting phosphatases could offer new strategies for modulating cell migration in various biological contexts.