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Magnesium-creatine supplementation effects on body water
L R Brilla1, M S Giroux, A Taylor
1Exercise and Sport Sciences Laboratory, Western Washington University, Bellingham, WA 98225-9067, USA.
Metabolism: Clinical and Experimental
|September 25, 2003
Summary
Magnesium-creatine chelate supplementation significantly increased intracellular water and quadriceps peak torque in athletes. This suggests improved cellular hydration and potential for enhanced muscle protein synthesis with creatine chelate.
Area of Science:
- Sports Science
- Nutritional Biochemistry
- Exercise Physiology
Background:
- Creatine supplementation is widely used to enhance athletic performance.
- Magnesium plays a crucial role in energy metabolism and muscle function.
- The combination of magnesium and creatine may offer synergistic benefits.
Purpose of the Study:
- To evaluate the effects of magnesium-creatine (MgCre) supplementation on body water composition and quadriceps muscle torque.
- To compare the efficacy of magnesium-creatine chelate (MgC-Cre) versus magnesium oxide plus creatine (MgO-Cre) and placebo.
Main Methods:
- A 2-week, randomized, double-blind study involving 35 subjects.
- Supplementation with MgC-Cre, MgO-Cre (800 mg Mg and 5 g Cre daily), or placebo (maltodextran).
- Assessment of total body water (TBW), extracellular water (ECW), and intracellular water (ICW) via bioimpedance, and quadriceps peak torque, total work, and power using an isokinetic device.
Main Results:
- Both MgCre groups showed increased body weight.
- MgC-Cre supplementation led to significant increases in ICW and ECW.
- Only the MgC-Cre group exhibited a significant increase in quadriceps peak torque; both MgCre groups showed increased power output.
Conclusions:
- Magnesium-creatine chelate supplementation positively influences cellular fluid compartments, specifically increasing intracellular water.
- The observed increase in ICW with MgC-Cre may enhance creatine uptake into muscle cells due to its osmotic properties.
- Increased cellular hydration from MgC-Cre supplementation could potentially support muscle protein synthesis and improve performance metrics like peak torque.