Related Experiment Video
Updated: Aug 31, 2026

In Vivo Electrophysiological Measurement of Compound Muscle Action Potential from the Forelimbs in Mouse Models of Motor Neuron Degeneration
Published on: June 15, 2018
Nemaline myopathy: a possible late complication of Hodgkin's disease therapy
Carol S Portlock1, Patrick Boland, Arthur P Hays
1Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA.
Abstract:
Patients who have undergone "mantle" field irradiation for Hodgkin's disease may develop symptomatic muscle atrophy in the treatment portal. This complication has received only scant attention in the clinical literature and its pathologic substrate has not been elucidated. We report the finding of nemaline myopathy in the previously irradiated and atrophic trapezius muscle of such a patient. Biopsy of clinically uninvolved gracilis muscle outside of the radiation portal revealed normal histology and ultrastructure. We are unaware of previous reports documenting such a phenomenon, which suggests that nemaline myopathy may evolve as a radiation-related disorder.
Related Concept Videos
Myasthenia Gravis: Overview and Treatment
These antibodies interfere with the function of the nicotinic receptors in three ways: by binding to the receptor and disrupting acetylcholine binding; by causing cross-linking of receptors which leads...
Myasthenia Gravis: Diagnostic Tests
The edrophonium test is a diagnostic tool for myasthenia gravis. It involves...
Huntington Disease l: Introduction
Myasthenia Gravis ll: Pathophysiology
Alterations in Muscle Tone lll
Cardiomyopathy III: Hypertrophic Cardiomyopathy