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Updated: Aug 31, 2026

Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay
Published on: September 9, 2012
Modulation of thrombophilia genes by environmental factors
Francesco Bernardi1, Giovanna Marchetti
1Dipartimento di Biochimica e Biologia Molecolare, Università degli Studi di Ferrara, Ferrara, Italy. ber@unife.it
Abstract:
The control of coagulation factor levels has a pivotal role in thrombophilia and known functional polymorphisms explain only a minor part of the coagulation factor level variance. Several studies provide evidence for i) interaction of polymorphisms and their combination with environmental factors; ii) molecular mechanisms mediating activation of coagulation proteins by environmental factors; iii) molecular mechanisms mediating transcriptional control of thrombophilia genes by environmental factors. However, the vast majority of molecular regulation by environmental factors is still unknown. Understanding of gene-gene and gene-environment interactions will require a detailed knowledge of regulatory regions of thrombophilia genes and of regulatory proteins.
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