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Trans-activation by hepatitis B virus X protein is mediated via a tumour promoter pathway

A S Kekulé¹, U Lauer, L Weiss

¹Max-Planck-Institut für Biochemie, Martinsried, Federal Republic of Germany.

Archives of Virology. Supplementum

|January 1, 1992

Abstract:

We have studied the c-myc gene as a possible target of HBV X protein in liver carcinogenesis. Our results indicate that trans-activation by X protein occurs via PKC/AP1 signal transduction, suggesting a possible two-step mechanism in HBV related liver carcinogenesis.

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