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Related Experiment Videos

Peripheral arterial disease and cognitive function.

Shari R Waldstein1, Carol F Tankard, Karl J Maier

  • 1Department of Psychology, University of Maryland, Baltimore County, Baltimore, MD 21250, USA. waldstei@umbc.edu

Psychosomatic Medicine
|September 26, 2003
PubMed
Summary
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Peripheral arterial disease (PAD) patients show poorer cognitive function than healthy individuals and those with hypertension, but better than stroke patients. This suggests a continuum of cognitive decline with worsening vascular disease.

Area of Science:

  • Neuroscience
  • Cardiovascular Medicine
  • Gerontology

Background:

  • Peripheral arterial disease (PAD) is linked to atherosclerosis in coronary and carotid arteries, increasing stroke risk.
  • Cognitive function in PAD patients before stroke is not well understood.
  • Vascular disease severity may correlate with cognitive impairment.

Purpose of the Study:

  • To assess cognitive performance in PAD patients compared to healthy controls, essential hypertensives, and stroke patients.
  • To investigate the relationship between vascular disease severity and cognitive function.
  • To determine if cognitive impairment follows a continuum with increasing cardiovascular disease severity.

Main Methods:

  • Neuropsychological testing of 38 PAD patients (mean ABI=0.67, Fontaine Class II).

Related Experiment Videos

  • Comparison with 23 healthy normotensive controls, 20 essential hypertensives, and 26 anterior ischemic stroke patients.
  • Utilized twelve neuropsychological tests assessing memory, concentration, executive function, and motor speed.

    • Main Results:

    • PAD patients performed worse than hypertensives and normotensives but better than stroke patients on seven cognitive tests.
    • Impairments were noted in nonverbal memory, concentration, executive function, perceptuo-motor speed, and manual dexterity.
    • Higher diastolic blood pressure and glucose levels correlated with poorer cognitive performance in PAD patients.

    Conclusions:

    • PAD patients demonstrate reduced cognitive function across multiple domains.
    • Findings support a continuum of cognitive impairment related to cardiovascular disease severity.
    • Highlights the need for preventative strategies to mitigate cognitive decline in PAD.