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Published on: April 11, 2025
Relationship between depression and pancreatic cancer in the general population
Caroline P Carney1, Laura Jones, Robert F Woolson
1Department of Internal Medicine, University of Iowa College of Medicine, Iowa City, Iowa 52242, USA. caroline-carney@uiowa.edu
Objective:
Prior research suggesting a relationship between pancreatic cancer and depression conducted on clinical populations has been subject to recall bias. We reexamined this association using longitudinal population-based data.
Methods:
This was a retrospective cohort study using longitudinal insurance claims data.
Results:
Men with mental disorders were more likely to develop pancreatic cancer than those without psychiatric claims (odds ratio 2.4, confidence interval 1.15-4.78). Depression more commonly preceded pancreatic cancer than it did other gastrointestinal malignancies (odds ratio 4.6, confidence interval 1.07-19.4) or all other cancers (odds ratio 4.1, confidence interval 1.05-16.0).
Conclusions:
Depression and pancreatic cancer are associated in the general population.
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