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Related Experiment Videos

Soluble CD14 and aortic stiffness in a population-based study.

Jacques Amar1, Jean B Ruidavets, Claire Bal Dit Sollier

  • 1Service de Médecine Interne et d'Hypertension Artérielle, CHU Toulouse, INSERM 558, Toulouse, France.

Journal of Hypertension
|September 26, 2003
PubMed
Summary
This summary is machine-generated.

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Soluble CD14 (sCD14) is linked to aortic stiffness in humans. This association persists even when accounting for age, blood pressure, and atherosclerosis, suggesting sCD14 as a potential independent marker for arterial health.

Area of Science:

  • Cardiovascular Research
  • Immunology
  • Biomarker Discovery

Background:

  • Soluble CD14 (sCD14) mediates monocyte activation by bacterial endotoxin.
  • sCD14 influences substances that can alter arterial wall characteristics.

Purpose of the Study:

  • To investigate the relationship between sCD14 and aortic stiffness in humans.
  • To analyze the impact of arterial structure and endothelial function on this relationship.

Main Methods:

  • A cross-sectional, population-based study involving 891 participants with complete data.
  • Measurements included carotid-femoral pulse wave velocity (PWV), blood pressure, common carotid intima-media thickness (IMT), plaque presence, and sCD14 levels.
  • Immunoenzymatic methods and ultrasonography were utilized.

Related Experiment Videos

Main Results:

  • Bivariate analyses showed positive associations between sCD14 and PWV, systolic BP, pulse pressure, IMT, plaque number, and von Willebrand factor activity.
  • After adjusting for confounders, sCD14 remained significantly associated with PWV (aortic stiffness).
  • No significant relationship was found between sCD14 and IMT, plaque presence, or blood pressure after adjustments.

Conclusions:

  • This study provides the first evidence in humans linking sCD14 to aortic stiffness.
  • The association between sCD14 and aortic stiffness is independent of age, blood pressure, and atherosclerosis.
  • sCD14 may serve as an independent marker for aortic stiffness.