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[Thrombocytopaenia in pregnancy].
Kjell Haram1, Eirik Søfteland, Tor Hervig
1Kvinneklinikken, Haukeland Universitetssykehus, Bergen. kjell.haram@broadpark.no
Summary
Thrombocytopaenia in pregnancy, a low platelet count below 150 x 10(9)/l, affects 5-12% of pregnancies. Various conditions, including gestational thrombocytopaenia and immune thrombocytopaenia (ITP), can cause this, necessitating clinical evaluation.
Area of Science:
- Obstetrics and Gynecology
- Hematology
- Perinatology
Context:
- Thrombocytopaenia, defined as a platelet count below 150 x 10(9)/l, is a significant concern during pregnancy.
- Gestational thrombocytopaenia is the most common cause, occurring in 5-12% of pregnancies, typically in the third trimester.
- Other causes include immune thrombocytopaenia (ITP), preeclampsia, HELLP syndrome, TTP, HUS, infections, and drug-induced conditions.
Purpose:
- To review the causes, definitions, and clinical implications of thrombocytopaenia in pregnancy.
- To differentiate between benign gestational thrombocytopaenia and more serious causes.
- To emphasize the importance of clinical assessment for managing low platelet counts during pregnancy.
Summary:
- Normal pregnancy platelet count ranges from 250-290 x 10(9)/l.
- Thrombocytopaenia is diagnosed with counts below 150 x 10(9)/l.
- Causes range from common benign gestational thrombocytopaenia to rarer conditions like ITP, preeclampsia, HELLP syndrome, TTP, HUS, infections, and drug-induced aetiologies.
Impact:
- Provides a concise overview for clinicians managing pregnant patients with low platelet counts.
- Highlights the differential diagnosis of thrombocytopaenia in pregnancy, aiding in accurate diagnosis and treatment.
- Underscores the need for individualized management based on clinical indications rather than solely relying on platelet counts.