Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Hormone replacement therapy and cardiovascular disease.

T W Meade¹, A Berra

¹MRC Epidemiology and Medical Care Unit, Northwick Park Hospital, Harrow, UK.

British Medical Bulletin

|April 1, 1992

Summary

Estrogen may protect against heart disease and stroke in women without a uterus. However, the cardiovascular impact of progestogens in women with a uterus is unknown and requires further research.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Unmet needs and relationship between general practitioners (GPs) and allergists living in Campania region (southern Italy).

European annals of allergy and clinical immunology·2020

Same author

Strong Reduction of the Effective Radiation Length in an Axially Oriented Scintillator Crystal.

Physical review letters·2018

Same author

Allergy in adolescent population (14-18 years) living in Campania region (Southern Italy). A multicenter study.

European annals of allergy and clinical immunology·2018

Same author

Allergic sensitization to common pets (cats/dogs) according to different possible modalities of exposure: an Italian Multicenter Study.

Clinical and molecular allergy : CMA·2018

Same author

Allergy in urban elderly population living in Campania region (Southern Italy). A multicenter study.

European annals of allergy and clinical immunology·2016

Same author

Investigation of the Electromagnetic Radiation Emitted by Sub-GeV Electrons in a Bent Crystal.

Physical review letters·2015

Area of Science:

Cardiovascular medicine
Endocrinology
Pharmacology

Background:

Estrogen therapy may offer protection against ischemic heart disease and stroke.
Estrogen replacement therapy (HRT) is suitable for post-hysterectomy women.
Cardiovascular effects of progestogens combined with estrogen in women with intact uteri are largely unknown.

Purpose of the Study:

To investigate the cardiovascular effects of progestogens used in hormone replacement therapy (HRT).
To address the complex and pressing issue of HRT indications and formulations for cardiovascular disease prevention.

Main Methods:

The abstract does not specify the methods used.
Highlights the need for randomized controlled trials (RCTs) to answer key questions.
Mentions the investigation into the feasibility of such trials.

Main Results:

Some progestogens negatively impact lipoprotein levels and may increase blood pressure.
Antithrombin III levels might influence estrogen response in various contexts.
The cardiovascular safety of combined HRT in women with uteri remains undetermined.

Conclusions:

Estrogen alone may be cardioprotective for women post-hysterectomy.
The cardiovascular safety of combined hormone replacement therapy (HRT) in women with intact uteri requires urgent investigation through randomized controlled trials.
Further research is critical to determine appropriate HRT indications and formulations for cardiovascular health.

Related Experiment Videos