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Magnetic Resonance Imaging Quantification of Pulmonary Perfusion using Calibrated Arterial Spin Labeling
Published on: May 30, 2011
Pediatric perfusion imaging using pulsed arterial spin labeling
Jiongjiong Wang1, Daniel J Licht, Geon-Ho Jahng
1Department of Radiology, University of Pennsylvania, Philadelphia 19104, USA. jwang@rad.upenn.edu
Insights
Pulsed arterial spin labeling (ASL) is a feasible technique for pediatric perfusion imaging, offering improved signal-to-noise ratio and cerebral blood flow in children compared to adults. This method shows promise for diagnosing pediatric neurologic disorders safely and effectively.
Area of Science:
- Radiology
- Neuroimaging
- Pediatric Imaging
Background:
- Assessing cerebral blood flow in children is crucial for diagnosing neurologic disorders.
- Conventional perfusion imaging techniques may have limitations in pediatric populations.
Purpose of the Study:
- To evaluate the feasibility of using pulsed arterial spin labeling (ASL) for pediatric perfusion imaging at 1.5 T.
- To compare ASL imaging parameters between healthy children and adults.
Main Methods:
- ASL perfusion imaging was performed on 7 neurologically normal children and 5 healthy adults at 1.5 T.
- Key metrics including signal-to-noise ratio (SNR), T1, M(0), arterial transit time, and temporal fluctuation were measured.
- ASL was also applied to 3 children with diagnosed neurologic disorders.
Main Results:
- Children exhibited a 70% higher ASL SNR and 30% greater absolute cerebral blood flow than adults.
- ASL SNR, T1, and M(0) values decreased linearly with age.
- No significant differences in transit time or temporal fluctuation were found between age groups.
- ASL demonstrated feasibility in diagnosing pediatric neurologic diseases.
Conclusions:
- Pulsed ASL is a viable and promising technique for pediatric perfusion imaging.
- ASL offers advantages in safety and enhanced image quality for pediatric neuroimaging.
- The findings support the use of ASL in the clinical evaluation of pediatric neurologic conditions.
Purpose:
To test the feasibility of pediatric perfusion imaging using a pulsed arterial spin labeling (ASL) technique at 1.5 T.
Materials And Methods:
ASL perfusion imaging was carried out on seven neurologically normal children and five healthy adults. The signal-to-noise ratio (SNR) of the perfusion images along with T1, M(0), arterial transit time, and the temporal fluctuation of the ASL image series were measured and compared between the two age groups. In addition, ASL perfusion magnetic resonance (MR) was performed on three children with neurologic disorder.
Results:
In the cohort of neurologically normal children, a 70% increase in the SNR of the ASL perfusion images and a 30% increase in the absolute cerebral blood flow compared to the adult data were observed. The measures of ASL SNR, T1, and M(0) were found to decrease linearly with age. Transit time and temporal fluctuation of the ASL perfusion image series were not significantly different between the two age groups. The feasibility of ASL in the diagnosis of pediatric neurologic disease was also illustrated.
Conclusion:
ASL is a promising tool for pediatric perfusion imaging given the unique and reciprocal benefits in terms of safety and image quality.
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