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Assessing Spatial Memory Impairment in a Mouse Model of Traumatic Brain Injury Using a Radial Water Tread Maze
Published on: July 17, 2017
[Erlangen Memory Center--a partial inpatient gerontopsychiatric facility]
Sabine Engel1, Andreas Mück, Klaus Christian Steinwachs
1Institut für Psychogeronotologie der Universität Erlangen-Nürnberg, Nägelsbachstrasse 25, 91052 Erlangen.
Abstract:
Two years ago the multiprofessional team of the Memory Centre Erlangen took up its work. Besides complete diagnoses of the cause of memory impairment, the work of the Memory Centre focusses on a special cognitive stimulation intervention. After completing assessment, namely self- and non-self anamnesis, psychometric tests and medical examinations, an individual treatment program for every patient will be development. In most instances the treatment program includes the participation in a special cognitive training. Adapting the SIMA-Program, psychomotor exercises, encoding strategies, retrieval techniques, attention and general cognitive speed arc trained in a group of 10 memory-impaired patients. After the 12-week treatment period a postintervention assessment is conducted in the same order as the preintervention assessment to evaluate the efficacy of the treatment. The data of a first evaluating study limited by sample size (20 patients) reveal that this intervention effects in a positive way the patient's cognitive performance. Patients with MCI (Mild Cognitive Impairment) show significant improvement in attention, general cognitive speed and short-term memory. Even patients with a dementia-diagnosis appeare to benefit from the cognitive stimulating intervention: After a 12-week time period no deterioration of cognitive ability is observed. Besides in attention, general cognitive speed and short-term memory an improvement can be reported.
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