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Updated: Aug 17, 2026

A 3D Organotypic Melanoma Spheroid Skin Model
Published on: May 18, 2018
Differentiation of pigmented conjunctival squamous cell carcinoma from melanoma
Jerry A Shields1, Carol L Shields, Steven Luminais
1Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA.
Abstract:
A 69-year-old man developed a pigmented conjunctival tumor that had a papillomatous vascular configuration but no leukoplakia. Although the pigmentation suggested melanoma clinically, histopathologic study of the resected lesion disclosed squamous cell carcinoma, with scattered dendritic melanocytes in the tumor. Conjunctival squamous cell carcinoma can be pigmented, similar to melanoma. The papillomatous arrangement of blood vessels in such tumors should strongly suggest squamous cell carcinoma despite the absence of leukoplakia.
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