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A continuing signal maintains NGF receptor expression in hypoglossal motor neurons after crush injury

D M Greeson1, L Moix, M Meier

  • 1Neurology Department, DVAMC, Nashville, TN 37212-2637.

Brain Research
|October 30, 1992
PubMed

Inhibition of axonal transport by vincristine applied to hypoglossal nerves 7 days after crush injury turns off the usual injured-induced expression of low affinity nerve growth factor receptor (p75NGFr). Vincristine applied proximal but not distal to the crush prevents p75NGFr induction. These results indicate that a continuing signal is axonally transported from the crush site that induces and maintains p75NGFr expression by injured motor neurons.

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