Ultrastructural studies on malignant lymphoma in dogs, with the use of computer imaging

Malignant lymphoma is one among the most often diagnosed malignant tumors in dogs. In the course of the disease lymphatic glands become enlarged and infiltrations form in internal organs or skin. Studies on the ultrastructure of neoplastic lymphocytes were carried out on a formalin-fixed and parafin-embedded material with a Hulquist and Karlsson's method. Numerous aplastic cells with large nuclei, abundan eu- or heterochromatin and unstabilised nucleolus were observed on TEM slides. The cells differed clearly from normal lymphocytes with highly condesed heterochromatin and stabilised nucleoli.