Related Experiment Videos
A versatile indium trichloride mediated Prins-type reaction to unsaturated heterocycles
Adrian P Dobbs1, Sebastien J J Guesné, Sasa Martinović
1School of Chemistry, University of Exeter, Stocker Road, Exeter EX4 4QD, UK. a.dobbs@exeter.ac.uk
The Journal of Organic Chemistry
|September 27, 2003
Abstract:
A versatile and high-yielding indium trichloride mediated cyclization reaction of silylated homoallylic alcohols, thiols, or amines with aldehydes or epoxides is described as a rapid route to a range of unsaturated heterocycles. The excellent diastereoselectivity observed offers a method of wide scope and generality.