Griffonianone D, an isoflavone with anti-inflammatory activity from the root bark of Millettia griffoniana
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Emmanuel Yankep1, Dieudonné Njamen, Maurice Tagatsing Fotsing
1Department of Organic Chemistry, Faculty of Science, University of Yaounde 1, P.O. Box 812 Yaounde, Cameroon.
Abstract:
A new isoflavone, griffonianone D (1), and the previously known compounds durmillone and odorantin were isolated from a chloroform extract of the root bark of Millettia griffoniana. The structure of 1 was established as (7E)-(6",7"-dihydroxy-3",7"-dimethyloct-2"-enyl)oxy-4'-methoxyisoflavone on the basis of its spectral data. The chloroform extract of the root bark of M. griffoniana and compound 1 showed anti-inflammatory effects in different experimental models of inflammation.