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Updated: Jul 28, 2026
09:29
Development and Maintenance of a Preclinical Patient Derived Tumor Xenograft Model for the Investigation of Novel Anti-Cancer Therapies
Published on: September 30, 2016
Review article: colorectal cancer chemotherapy.
S Gill1, R R Thomas, R M Goldberg
1British Columbia Cancer Agency, Vancouver, BC, Canada.
Alimentary Pharmacology & Therapeutics
|September 27, 2003
Summary
Advances in chemotherapy have improved survival for colorectal cancer patients. Newer agents and targeted therapies offer expanded options for advanced and localized disease management.
Area of Science:
- Oncology
- Medical Oncology
Background:
- Colorectal cancer is a significant global cause of cancer mortality.
- Chemotherapeutic management has evolved through clinical trials.
Purpose of the Study:
- To review the current chemotherapeutic management of colorectal cancer.
- To highlight advances in treatment options for advanced and localized disease.
Main Methods:
- Review of clinical trial data and therapeutic advancements.
- Analysis of newer chemotherapeutic agents and targeted therapies.
Main Results:
- Newer agents like capecitabine, irinotecan, and oxaliplatin have expanded treatment options.
- Adjuvant systemic chemotherapy improves survival for resected, high-risk, localized colorectal cancer.
- Survival improvements are noted with expanded therapeutic options.
Conclusions:
- Chemotherapy remains a cornerstone in colorectal cancer management.
- Ongoing research focuses on novel regimens, predictive testing, and targeted therapies.
- Integration of new agents and strategies enhances patient outcomes.
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