Related Experiment Video
Updated: Aug 13, 2026
07:57
Protocols for Vaginal Inoculation and Sample Collection in the Experimental Mouse Model of Candida vaginitis
Published on: December 8, 2011
Resolution of vulvitis circumscripta plasmacellularis with topical imiquimod: two case reports
H L Ee1, G Yosipovitch, R Chan
1National Skin Centre, 1 Mandalay Road, Singapore 308205, Republic of Singapore. ee_melvin@hotmail.com
The British Journal of Dermatology
|September 27, 2003
Summary
Vulvitis circumscripta plasmacellularis (VCP), a rare condition, often resists treatment. Topical imiquimod effectively resolved VCP lesions in two patients resistant to other therapies.
Area of Science:
- Dermatology
- Gynecologic Dermatology
- Vulvar Pathology
Background:
- Vulvitis circumscripta plasmacellularis (VCP) is a rare vulvar condition.
- VCP is known for its resistance to conventional treatments.
- Previous treatments like intralesional interferon-alpha have shown efficacy but carry risks such as myelosuppression.
Observation:
- Two cases of VCP are presented.
- Lesions in both patients were refractory to antibiotics, topical corticosteroids, and oral corticosteroids.
- Topical imiquimod was used as a treatment trial for these resistant cases.
Findings:
- Topical imiquimod treatment led to complete resolution of VCP lesions in both reported cases.
- This suggests imiquimod's potential efficacy in managing recalcitrant VCP.
- The mechanism may involve imiquimod's ability to induce interferon-alpha production.
Implications:
- Topical imiquimod represents a promising therapeutic option for vulvitis circumscripta plasmacellularis.
- It offers an alternative for patients with treatment-resistant VCP.
- Further research into imiquimod for VCP is warranted to confirm these findings and assess long-term outcomes.
Related Concept Videos
01:27Acne Infection
Acne is a multifactorial skin condition primarily affecting adolescents and young adults, with a global prevalence estimated to exceed 75% in this demographic. The condition is characterized by the formation of comedones (blackheads and whiteheads), papules, pustules, nodules, and, in severe cases, cysts, particularly in areas rich in sebaceous glands such as the face, neck, chest, and back. The pathogenesis involves increased sebum production, follicular hyperkeratinization, colonization by...
01:23Genital Herpes
Genital herpes is a sexually transmitted infection primarily caused by herpes simplex virus type 2 (HSV-2), though herpes simplex virus type 1 (HSV-1) is increasingly implicated in genital infections, particularly among younger populations. Transmission occurs mainly through sexual contact, with asymptomatic viral shedding serving as a major route of spread. This characteristic makes HSV-2 difficult to control at a population level, as individuals may unknowingly transmit the virus even in the...
01:20Candidiasis
Candidiasis is a fungal infection caused by opportunistic species of Candida. It can affect various anatomical sites, including the skin, oral cavity, nails, and genitourinary tract. Among its forms, vaginal candidiasis is the most common type of mucosal infection. It typically results from the overgrowth of Candida albicans in the vaginal mucosa. Under normal conditions, C. albicans exists as a commensal organism within the vaginal microbiota, regulated by the dominance of lactobacilli, which...
01:18Trichomoniasis
Trichomonas vaginalis is a flagellated protozoan parasite and the causative agent of trichomoniasis, one of the most prevalent non-viral sexually transmitted infections in the United States. This extracellular parasite primarily colonizes the lower genitourinary tract in women—particularly the vagina—and in men, the urethra and prostate. Its structural and functional adaptations enable its survival, motility, and pathogenicity within the host environment.Structural Features and Host EntryT.